Dengue fever is a mosquitoborne tropical disease caused by the dengue virus. Dengue often presents in the form of large outbreaks. Dengue fever its diagnosis, treatment, prevention and control. Guidelines for diagnosis, treatment, prevention and control by the world health organization who in 20091, the need to provide more training to healthcare workers in this area has become increasingly evident. Dengue fever, also known as breakbone fever, is a mosquitoborne. As the disease spreads to new geographical areas, the frequency of the outbreaks is increasing. Dengue and dengue hemorrhagic fever frequently asked questions. This is an observational, descriptive and retrospective study of 154 patients with clinical and serological diagnoses of dengue fever who, in the period from january to may 2008, were admitted in a tertiary state hospital in the city of fortaleza that is a referral center for infectious diseases.
No severe clinical forms were reported, and there were no fatalities. Dengue fever is an infectious disease carried by mosquitoes and caused by any of four related dengue viruses. Dengue fever is an acute viral infection characterized by fever. A test approved in 2012, which is a denv reverse transcription pcr. It was the first sustained transmission of dengue in the european union since the 1920s. Dengue chapter 4 2020 yellow book travelers health. Infection with the dengue virus can cause severe flulike symptoms. Initially, the unit functioned with a who consultant and a national counterpart, who, after further training in epidemiology, was appointed in 1961, as the epidemiologist of the department of health services. Dengue fever is transmitted by the bite of an aedes mosquito infected with a dengue virus. Dengue hemorrhagic fever is a rare but more severe form of dengue infection that can be fatal if not recognized and treated with supportive care. Mild dengue fever causes a high fever, rash, and muscle and joint pain. Causes, prevention and recent advances find, read and cite all the research you need on researchgate. Further events were held in 2012 in yangon, myanmar and in 20 in vietnam.
The invention further relates to a vaccine composition which comprises a vdv2 strain. Dengue is a self limiting acute mosquito transmitted disease characterized by fever, headache, muscle, joint pains, rash, nausea and vomiting. Dengue and severe dengue world health organization. The invention relates to live attenuated vdv2 veroderived vaccine dengue serotype 2 strains which have been derived from the wildtype dengue2 strain 16681 by passaging on pdk and vero cells. The rapidly expanding global footprint of dengue is a public health challenge with an. European centre for disease prevention and control, 2012. The first dengue vaccine, dengvaxia cydtdv by sanofi pasteur, was first licensed in december, 2015, in mexico. In a small proportion of cases, the disease develops into severe dengue, also.
Dengue, dengue virus, dengue hemorrhagic fever, dengue fever, flavivirus, aedes mosquitoes, dhf, df, dss. Dengue fever nord national organization for rare disorders. Use our dc health service telephone directory to view the telephone numbers for various dc. Dengue is transmitted to people by the bite of an aedes mosquito that is infected with a. They cause a disease known as dengue fever, but they can also cause a more severe form of illness known as dengue hemorrhagic fever or severe dengue, which potentially can be fatal. Other symptoms may include shaking chills, diarrhea, and vomiting. A new who strategy for dengue control and prevention for the period 2012 20 is being implemented with the main aim to diminish dengue burden. This suggests that the amount of virus is less important than the form in which it is presented to the immune system. September 27, 2012 first confirmed case of locally acquired dengue fever in 2012, miamidade county on september 11, 2012, the miamidade county health department was notified by a commercial laboratory of a suspected case of west nile virus. Pdf on jan 1, 2016, anum jaweria and others published dengue fever. The hemorrhagic form of dengue fever is more serious and is associated with loss of appetite, vomiting, high fever, and abdominal pain.
Annex 1 summary of information extracted for aedes and dengue. Pdf the endemic area for dengue fever extends over 60 countries, and approximately 2. The climatic suitability for dengue transmission in. The primary form of dengue fever is characterized by a skin rash and a high fever with severe pain in the head and muscles. Dengue reported in england, wales and northern ireland. It is a mosquitoborne, single positivestranded rna virus of the family flaviviridae. Health experts have known about dengue fever for more than 200 years. Unfortunately, progress towards development of effective therapeutics has been slow, despite notable advances in the understanding of disease pathogenesis and considerable investment in antiviral drug discovery. In 2012, an outbreak of dengue on the madeira islands of portugal. Dengue is a selflimited, systemic viral infection transmitted between humans by mosquitoes. Five serotypes of the virus have been found, all of which can cause the full spectrum of disease. The disease is often diagnosed incorrectly because the symptoms are similar to influenza and other viruses. Who fact sheet dengue and severe dengue provides key facts, definition. Symptoms include fever, headache, muscle and joint pains, and a.
Symptoms typically begin three to fourteen days after infection. The rash that commonly forms during the recovery from dengue fever with its classic islands. Dengue is common in more than 100 countries around the world. Dengue is a selflimited, systemic viral infection transmitted between humans by. Nevertheless, scientists understanding of dengue virus may be simplistic, as rather than distinct antigenic groups, a continuum appears.
District of columbia department of health division. The dengue viruses, a group of four closely related viruses, are transmitted to humans through the bite of an infected mosquito. Dengue virus infections can cause a wide clinical spectrum of disease, from a mild febrile illness known as dengue fever through to severe dengue, previously known as dengue haemorrhagic fever dhf, which is characterized by capillary leakage leading to hypovolaemic shock, organ impairment and bleeding complications. In 1950s, during dengue epidemic in the philippines and thailand, a severe form, known as dengue hemorrhagic fever, was first recognized.
Initial symptoms are the same as dengue but are followed by bleeding problems such as easy bruising, skin hemorrhages, bleeding from the nose or gums, and. Iatrogenic fluid overload in the management may further complicate the picture. Dengue fever is a viral disease that is spread by infected mosquitoes. Treatment of dengue fever article pdf available in infection and drug resistance 51. Dengue fever df, caused by dengue virus, is an arboviral disease characterized by an initial. Dengue hemorrhagic fever is characterized by a fever that lasts from 2 to 7 days, with general signs and symptoms that could. This disease used to be called breakbone fever because it sometimes causes severe joint and muscle pain that feels like bones are breaking.
Dengue gcp guidelines pdf services institute of medical. Dengue and dengue haemorrhagic fever introduction dengue is a mosquitoborne infection, which in recent years has become a major international public health concern. Estimating the size of aedes aegypti populations from. In some cases it leads to dengue haemorrhagic fever, also known as severe dengue, which affects the bodys vascular system how blood moves through the body. Dengue and dengue hemorrhagic fever frequently asked. Dengue fever is a virus transmitted to humans through bites from the aedes mosquito, a daybiting mosquito. Dengue fever, also known as breakbone fever, is a mosquitoborne infectious tropical disease caused by the dengue virus. Dengue denggey fever is a mosquitoborne disease that occurs in tropical and subtropical areas of the world. The infection is endemic in more than 100 countries, particularly the south east asia region, western pacific region, and the americas. If you think you have dengue pdf icon pdf 1 page see a healthcare provider if you develop a fever or have symptoms of dengue. Dengue is a febrile illness that can have a fatal outcome in severe cases. Summary dengue fever, a very old disease, has reemerged in the past 20 years with an expanded geographic distribution of both the viruses and the mosquito vectors, increased epidemic activity, the development of hyperendemicity the cocirculation of multiple serotypes, and the emergence of dengue hemorrhagic fever in new geographic regions. A severe form of dengue fever, also called dengue hemorrhagic fever, can cause severe bleeding, a sudden drop in blood pressure shock and death. The mosquito becomes infected when it bites a person with dengue virus in their blood.
Often clinical details such as date of onset and symptoms, relevant past vaccination status and travel history such. Dengue viruses are spread to people through the bite of an infected aedes species ae. Guidelines for dengue fever and dengue haemorrhagic fever. Dengue fever is a globally important arboviral infection transmitted by the aedes genus of mosquito primarily a aegypti, but also a albopictus, found in tropical and subtropical regions. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash. Clinical and laboratory characteristics of patients with dengue hemorrhagic fever manifestations and their transfusion profile. Dengue fever is a disease spread by the aedes aegypti mosquito and is caused by one of four dengue viruses. Dengue fever df is caused by an arbovirus and spread by aedes mosquitoes. Dengue is found in tropical and subtropical regions around the world, predominantly in urban and semiurban areas.
This form of dengue fever can lead to shock, bleeding and can be fatal. Cydtdv is a live recombinant tetravalent vaccine based on the yellow fever 17d backbone and is registered as a 3dose vaccine given on a 06. It is a caused by a flavivirus with four distinct serotypes dv1, dv2, dv3, and dv4. Dengue fever is a viral infection spread by mosquitoes that causes symptoms such as high fever, severe headache and pain behind the eyes, bleeding and easy bruising. Dengue fever is a viral infection that can cause lifethreatening illness, milder flulike illness, or no symptoms at all. Treat the symptoms of dengue and see your healthcare provider. Blood testing detects the dengue virus or antibodies produced in response to dengue infection. Dengue hemorrhagic fever and dengue shock syndrome some patients with dengue fever go on to develop dengue hemorrhagic fever dhf, a severe and sometimes fatal form of the disease. The epidemiology unit was established in 1959 with assistance from world health organization who to strengthen surveillance of communicable diseases.
116 1395 1363 246 730 652 1588 1087 1354 40 1439 1108 1246 1013 648 631 46 341 739 1477 627 928 1379 370 1293 5 1546 1036 476 1590 424 1190 1233 1265 120 698 320 485 699 1108 934 853